An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma

An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma

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Differentiated thyroid 14765-prb-a01 cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare.We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology.A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer.After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made.Two cycles of radioactive iodine were performed.

Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations.The results showed that the cutaneous metastasis was BRAF wild-type and viqua-f4 TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers.